Natural killer cells commute death sentence
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چکیده
منابع مشابه
Natural killer cells commute death sentence
Sphingolipid imbalance can take out an eye Y onamine et al. report that the relative amounts of two sphingolipids control the breakdown of light-sensing proteins and determine whether eye cells survive. Sphingolipids aren’t just building blocks of membranes. Some of the molecules, such as sphingosine 1 phosphate (S1P) and dihydrosphingosine 1 phosphate (DHS1P), take part in signaling pathways t...
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Background: Schizophrenia has been associated with altered immunity. Different studies regarding natural killer cell activity (NKA) in schizophrenic patients have shown inconsistent results. Objectives: To evaluate NK cell activity in schizophrenic patients in comparison with healthy control individuals. Methods: 30 medication-free schizophrenic patients and 41 healthy sex, age and smoking st...
متن کاملNatural killer cells
What do they do? NK cells are equipped with cytotoxic granules that contain the arsenal of cytotoxic molecules used in killing virally infected and cancerous cells. They recognize their targets, in part, by means of activating signals that are only just beginning to be identified, but also by detecting cells that are deficient in cell-surface class I molecules of the major histocompatibility co...
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The Src homology (SH) 2/SH3 domain-containing protein Grb2 and the oncoprotein Shc have been implicated in a highly conserved mechanism that regulates p21 ras activation. We investigated the involvement of these adaptor proteins in the signaling pathway induced by CD16 or interleukin (IL) 2R triggering in human natural killer (NK) cells. Both p46 and p52 forms of Shc were rapidly and transientl...
متن کاملHuman natural killer cells.
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that belong to the innate immune system because unlike T or B lymphocytes of the adaptive or antigen-specific immune system, NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration. During the past 2 decades there has been a substantial gain in ou...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2011
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1924iti3